designed to trigger both a helper- and cytotoxic T-cell response in the patients, ensuring a broad and lasting immune response. The Targovax peptides are designed for induction of RAS mutation specific T-helper cells through presentation on HLA class II molecules on the surface of Antigen Presenting Cells (APCs), but also for natural processing to potential HLA class I epitopes and induction of RAS mutation specific cytotoxic T cells.The T helper (Th) cells have a central and critical role in coordination of immune reactions and are often referred to as the "generals" and "conductors" of the immune system. The drug candidate has a strong historical background including clinical data. The clinical data indicate both an increase of mean survival and long-term survivors. The drug is well tolerated with a low degree of side effects. Inventors of the technology and the Radium Hospital Research Foundation established Targovax in 2010.