and toxic chemicals and carcinogens EMS, MMS, nitrogen mustard, radioactive iodine and cigarette smoke extract induced DNA damage. Yel002 and CJ010 reduced radiation induced leukemia from 90% to 40% and the spontaneous frequency from 10% to 0%. Weekly subcutaneous injections of Yel002 also extended the life expectancy of cancer prone Atm deficient mice of which usually 90% die from lymphoma for 16 weeks which is about 12 years of human life expectancy. Yel002 also extended the life span in a senescence assay after radiation 2 fold and spontaneous senescence 15%. The mechanism of action seems to be induction of DNA repair, namely ATM signalling, homologous recombination, and end joining, base excision repair and chromosome segregation functions.