serve as invaluable pre-clinical tools to help direct drug discovery research. RNAi-GEMMs are a unique and superior alternative to knockout mice that increase the confidence of drug discovery research prior to entering clinical trials. The ability to transiently suppress a specific gene target within the whole organism makes RNAi-GEMMs an effective tool to be used for target identification and/or validation as well as assessment of target efficacy and toxicity. Transgenic RNAi rodents will undoubtedly become indispensible to the pharmaceutical and biotechnology industry by directing the development of effective and well-tolerated therapeutic strategies to combat the leading ailments of humankind.