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HI-STEM conducts fundamental and translational research on normal and malignant stem cells to understand their biology and role in cancer. The institute studies hematopoietic stem cells, leukemic stem cells, solid tumor and metastasis-initiating cells, and the tumor microenvironment. Its researchers investigate mechanisms of dormancy, therapy
resistance, DNA damage, epigenetic regulation, and inflammatory stress in stem cells. HI-STEM develops experimental models and omics-based approaches to identify biomarkers, stratify cancer subtypes, and characterize minimal residual disease. The organization collaborates with clinical, academic, and industry partners to design diagnostic tools and therapeutic strategies that monitor and target leukemic and solid tumor stem cells and metastatic disease. Its work aims to inform new treatments and improve response prediction in oncology and regenerative medicine.
