structure refinement, autoPROC for automated X-ray diffraction data processing, SHARP/autoSHARP for experimental phasing, and Rhofit for automated ligand fitting. Additional tools such as GRADE and Grade2 generate geometric restraints for small molecules, while Pipedream combines data processing, refinement and ligand fitting into automated pipelines. STARANISO provides diffraction anisotropy analysis and anisotropic data correction. Academic laboratories, structural biology facilities and pharmaceutical research groups use these tools to support tasks such as high-throughput fragment screening, ligand validation and optimization of crystallographic data quality.