Primary Job Title James B Duke Professor of Medicine Primary Organization 
Duke University School of Medicine
Location Durham, North Carolina, United States Regions Research Triangle, East Coast, Southern US Gender Male
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Lefkowitz has spent his entire research career working on the molecular and regulatory properties of the G protein coupled receptor super family, the largest family of cell surface receptors and the commonest target for therapeutic drugs. Using the beta2-adrenergic receptor and related receptors as his models he discovered their universal molecular
and regulatory properties such as their seven transmembrane spanning architecture and desensitization by G protein coupled receptor kinases and beta-arrestins. For his discoveries he has been recognized by numerous awards, including the Gairdner Foundation International Award, the Shaw Prize in Life Science and Medicine, the Institut de France Fondation Lefoulon-Delalande Grand Prix for Science Award, the Jesse Stevenson Kovalenko Medal from the National Academy of Sciences, the Albany Medical Prize in Medicine and Biomedical Research and the United States National Medal of Science.
In 2012, Lefkowitz shared the Nobel Prize in Chemistry. Lefkowitz has been a member of Five Prime’s Scientific Advisory Board since October 2002.
