capturing of oligonucleotides, including rare and fragile circulating-free DNA (cfDNA) molecules, at a single molecule level. Instead of standard size selection-based nucleic acid isolation and purification methods, traditionally used in the industry, ZipPrime’s capturing technology centres around magnetic particle-based novel primer structures which can target each and every oligonucleotide molecules as a simple, elegant, accurate and low cost solution. These versatile magnetic particle-based-based structures also allow the reusable storage and enrichment of captured oligonucleotides without the need for complicated devices or protocols. An initial UK patent application for this technology was filed in 2012 and a following PCT application in 2014. ZipPrime’s intellectual property (IP) of core nucleic acid capturing, storage and enrichment technology is protected by a patent portfolio consisting of a patent family based upon the PCT application published in 2014 and entered the National/Regional Phase in key territories and ZipPrime’s first patent has been granted in February 2017.