Ardelyx develops novel, first-in-class oral therapeutics to correct mineral metabolism and metabolic disorders. The Company's molecules, whose systemic exposure is severely restricted, target transporters and receptors, modulating the uptake of nutrients or inducing secretion of key hormones to produce a therapeutic benefit in patients. The Company's non-systemic products act from within the intestines to avoid potential side effects that could occur with systemic exposure. The Company's lead product, RDX5791, a minimally-absorbed, orally administered NHE3 sodium transport inhibitor, is being developed both for constipation-predominant irritable bowel syndrome (IBS-C) and for prevention of excess dietary sodium absorption, a new treatment modality for high blood pressure. RDX5791 is in phase 2 for IBS-C and a dose-ranging/regimen study for inhibition of excess dietary sodium absorption. Ardelyx is also developing RDX002, a minimally-absorbed, orally administered NaP2b phosphate transport inhibitor for the inhibition of phosphate absorption in patients with chronic kidney disease, and RDX009, a minimally-absorbed, orally administered TGR5 agonist for the treatment of type 2 diabetes through direct induction of intestinal incretins such as GLP-1 and PYY. Both RDX002 and RDX009 are in preclinical development. To date, Ardelyx has raised $56M in venture and angel funding since it was founded in 2007. Ardelyx is located in Fremont, California.
Funding Rounds (4) - $222.79MUpdate
Current Team (11)Update
Board Members and Advisors (2)Update
|Jul 19, 2016||silicontap.com - Ardelyx Picks Up $110M In PIPE From Venture Investors|
|Jul 15, 2016||PRNewswire All - Ardelyx to Raise $110 Million in a Private Placement|
|Apr 1, 2016||PRNewswire UK All - Diarrhea Pipeline Market Research Report H1 2016|
|Mar 4, 2016||PRNewswire All - Ardelyx Reports Fourth Quarter and Full-Year 2015 Financial Results|
|Jan 8, 2016||PRNewswire All - Ardelyx Announces Pricing of Public Offering of Common Stock|
|Jan 6, 2016||PRNewswire All - Ardelyx Announces Proposed Public Offering of Common Stock|
|Dec 17, 2015||PRNewswire UK All - Global Hyperphosphatemia Drugs Market CAGR Growth of 10.71% overy Four Years - Analysis, Technologies & Forecast 2015-2019|
|Dec 11, 2015||Business Wire - Research and Markets: Non-Alcoholic Steatohepatitis Therapeutics Pipeline Review 2015|
34175 Ardenwood Blvd.
Fremont, CA 94555