I spend most of my day in Emacs, which is the only text editor ever invented (it’s also a Tetris client, operating system, and punchline).
I use Alfred mostly for launching programs and finding files, but recently started using it to view and edit my clipboard history. That’s been a game changer.
I take a lot of screenshots for some reason and use Skitch for that (version 1—the new version is a totally different app). And of course: OmniFocus, Evernote, TextExpander, 1Password, and Chrome.