Comerica is a multi-faceted financial services corporation.
| Company | Date | Round | Size | Participants |
| BrightRoll | 11/11 | Series C | $30M | 5 |
| Market Force Information | 9/11 | Debt | $15M | 6 |
| Highwinds | 5/11 | Unattributed | $50M | 2 |
| BookRenter.com | 2/11 | Unattributed | $40M | 6 |
| Tilera | 1/11 | Series D | $45M | 8 |
| WealthEngine | 1/11 | Unattributed | $2.5M | 1 |
| PlayFirst | 10/10 | Unattributed | $9.2M | 5 |
| ebridge | 9/10 | Series A | $2.5M | 1 |
| BookRenter.com | 9/10 | Debt | $4.5M | 1 |
| Spectrum K12 School Solutions | 10/08 | Unattributed | $7.4M | 4 |
| PlumChoice | 4/08 | Series C | $8M | 2 |
| Aerovance | 3/08 | Debt | $20M | 2 |
| maniaTV | 3/08 | Debt | $2M | 1 |
| Harmony Information Systems | 10/07 | Series B | $28M | 4 |
| Hyperion Therapeutics | 10/07 | Debt | $15M | 2 |
| Propel Fuels | 8/07 | Debt | $4M | 1 |
| PlumChoice | 8/07 | Unattributed | $7.6M | 2 |
| Center'd | 5/07 | Debt | $500k | 1 |
| InGrid | 6/06 | Debt | $1.5M | 1 |
| Spot Runner | 1/06 | Series A | $10M | 3 |